Banting &amp; Best / en Post-meal insulin surge not necessarily a bad thing: Study /news/post-meal-insulin-surge-not-necessarily-bad-thing-study <span class="field field--name-title field--type-string field--label-hidden">Post-meal insulin surge not necessarily a bad thing: Study</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2024-01/GettyImages-1434438081-crop.jpg?h=81d682ee&amp;itok=6tTvf07I 370w, /sites/default/files/styles/news_banner_740/public/2024-01/GettyImages-1434438081-crop.jpg?h=81d682ee&amp;itok=5QdIeMLo 740w, /sites/default/files/styles/news_banner_1110/public/2024-01/GettyImages-1434438081-crop.jpg?h=81d682ee&amp;itok=SYWrF02D 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2024-01/GettyImages-1434438081-crop.jpg?h=81d682ee&amp;itok=6tTvf07I" alt="man eating a big bowl of pasta, wine and salad"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Christopher.Sorensen</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2024-01-12T15:24:44-05:00" title="Friday, January 12, 2024 - 15:24" class="datetime">Fri, 01/12/2024 - 15:24</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p><em>(photo by&nbsp;Violeta Stoimenova/Getty Images)</em></p> </div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/jovana-drinjakovic" hreflang="en">Jovana Drinjakovic</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/breaking-research" hreflang="en">Breaking Research</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/sinai-health" hreflang="en">Sinai Health</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/banting-best" hreflang="en">Banting &amp; Best</a></div> <div class="field__item"><a href="/news/tags/diabetes" hreflang="en">Diabetes</a></div> </div> <div class="field field--name-field-subheadline field--type-string-long field--label-above"> <div class="field__label">Subheadline</div> <div class="field__item">Researchers explored the cardiometabolic implications of insulin response over the long term in a way that accounts for baseline blood sugar levels</div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Researchers at Sinai Health and the University of Toronto have unearthed new information about the relationship between insulin levels after eating and long-term heart and metabolic health – research that upends the notion that insulin surge following food intake is a bad thing.</p> <p>On the contrary, the researchers said, it could be an indicator of good health to come.</p> <p>Led by&nbsp;<strong>Ravi Retnakaran</strong>, clinician-scientist at the&nbsp;Lunenfeld-Tanenbaum Research Institute (LTRI), part of Sinai Health, the study – which was&nbsp;<a href="https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00540-0/fulltext">published in the Lancet group’s online journal&nbsp;<em>eClinicalMedicine</em></a>&nbsp;– set out to explore how insulin levels after meals impact cardiometabolic health. While past research has yielded conflicting results, suggesting both harmful and beneficial effects, this new study aimed to provide a clearer picture over an extended period of time.</p> <p>“The suggestion has been made by some people that those insulin peaks have deleterious effects by promoting weight gain,” said Retnakaran, who is a professor in the&nbsp;department of medicine, the&nbsp;Institute of Medical Science&nbsp;and the&nbsp;Banting &amp; Best Diabetes Centre&nbsp;in Թϱ’s Temerty Faculty of Medicine. “Sometimes I see patients in the clinic who have adopted this notion&nbsp;– maybe from the internet or what they're reading&nbsp;– that they can't have their insulin level go too high.</p> <p>“[But] the science is just not conclusive enough to support this notion. Most studies on this topic were either conducted over a short period of time or were based on insulin measurements in isolation that are inadequate and can be misleading.”</p> <p>While it’s normal for insulin levels to rise after eating to help manage blood sugar, the concern is whether a rapid increase in insulin after a meal could spell bad health. Some believe an insulin surge, especially after eating carbohydrates, promotes weight gain and contributes to insulin resistance, which occurs when the body's cells don't respond well to insulin, making it harder to control blood sugar levels and increasing the risk of type 2 diabetes.</p> <p>Retnakaran’s team looked at cardiometabolic implications of insulin response over the long term in a way that accounts for baseline blood sugar levels. That’s key because each person has an individual insulin response that varies depending on how much sugar is in the blood.</p> <p>The study followed new mothers because the insulin resistance that occurs during pregnancy makes it possible to determine their future risk of type 2 diabetes. Over 300 participants were recruited during pregnancy, between 2003 and 2014, and underwent comprehensive cardiometabolic testing – including glucose challenge tests at one, three and five years after giving birth. The glucose challenge test measures glucose and insulin levels at varying times after a person has had a sugary drink containing 75 grams of glucose and following a period of fasting.</p> <p>While the test is commonly used by health professionals, it can be misleading if one does not account for baseline blood sugar. &nbsp;</p> <p>“It’s not just about insulin levels; it’s about understanding them in relation to glucose,” Retnakaran said, pointing out that this is where many past interpretations fell short. A better measurement, he said, is the corrected insulin response (CIR) that accounts for baseline blood glucose levels, and which is slowly gaining prominence in the field.</p> <p>The study revealed some surprising trends. As the corrected insulin response increased, there was a noticeable worsening in waist circumference, HDL (good cholesterol) levels, inflammation and insulin resistance&nbsp;– as long as one&nbsp;did not consider accompanying factors. However, these seemingly negative trends were accompanied by better beta-cell function. Beta cells produce insulin and their ability to do so is closely associated with diabetes risk. In other words, the better beta cells function, the lower the risk.</p> <p>“Our findings do not support the carbohydrate-insulin model of obesity,” said Retnakaran. “We observed that a robust post-challenge insulin secretory response – once adjusted for glucose levels – is only associated with the beneficial metabolic effects.”</p> <p>“Not only does a robust post-challenge insulin secretory response not indicate adverse cardiometabolic health, but rather it predicts favorable metabolic function in the years to come.”</p> <p>In the long run, higher corrected insulin response levels were linked with better beta-cell function and lower glucose levels, without correlating with BMI, waist size, lipids, inflammation or insulin sensitivity and resistance. Most importantly, women who had the highest CIR had a significantly reduced risk of developing pre-diabetes or diabetes in the future.</p> <p>“This research challenges the notion that high post-meal insulin levels are inherently bad and is an important step forward in our understanding of the complex roles insulin plays in regulation of metabolism,” said&nbsp;<strong>Anne-Claude Gingras</strong>, director of LTRI and vice-president of research at Sinai Health, who is also a professor of&nbsp;molecular genetics&nbsp;at Temerty Medicine.</p> <p>Retnakaran hopes the team’s findings will reshape how medical professionals and the public view insulin's role in metabolism and weight management.</p> <p>“There are practitioners who subscribe to this notion of higher insulin levels being a bad thing, and sometimes are making recommendations to patients to limit their insulin fluctuations after the meal. But it’s not that simple,” he said.</p> <p>The research was supported by grants from the Canadian Institutes of Health Research.</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Fri, 12 Jan 2024 20:24:44 +0000 Christopher.Sorensen 305282 at Insulin 100: Parks Canada unveils commemorative bronze plaque at Թϱ /news/insulin-100-parks-canada-unveils-commemorative-bronze-plaque-u-t <span class="field field--name-title field--type-string field--label-hidden">Insulin 100: Parks Canada unveils commemorative bronze plaque at Թϱ</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2023-04/2021-11-12-Insulin%20Plaque%20Unveiling.%20%289%29-crop.jpg?h=afdc3185&amp;itok=caB-PAg0 370w, /sites/default/files/styles/news_banner_740/public/2023-04/2021-11-12-Insulin%20Plaque%20Unveiling.%20%289%29-crop.jpg?h=afdc3185&amp;itok=moKAY81X 740w, /sites/default/files/styles/news_banner_1110/public/2023-04/2021-11-12-Insulin%20Plaque%20Unveiling.%20%289%29-crop.jpg?h=afdc3185&amp;itok=xwdOpPIX 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2023-04/2021-11-12-Insulin%20Plaque%20Unveiling.%20%289%29-crop.jpg?h=afdc3185&amp;itok=caB-PAg0" alt="the insulin plaque is unveiled at a ceremony at the University of Toronto"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>rahul.kalvapalle</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2021-11-12T15:15:21-05:00" title="Friday, November 12, 2021 - 15:15" class="datetime">Fri, 11/12/2021 - 15:15</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p>Christine Allen, Թϱ’s associate vice-president and vice-provost, strategic initiatives, and Christine Loth-Brown, vice-president, Indigenous Affairs and Cultural Heritage, Parks Canada, unveil the plaque (Photo by Johnny Guatto)</p> </div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/rahul-kalvapalle" hreflang="en">Rahul Kalvapalle</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/city-culture" hreflang="en">City &amp; Culture</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/insulin-100" hreflang="en">Insulin 100</a></div> <div class="field__item"><a href="/news/tags/sinai-health" hreflang="en">Sinai Health</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/toronto-general-hospital" hreflang="en">Toronto General Hospital</a></div> <div class="field__item"><a href="/news/tags/myhal-centre-engineering-innovation-entrepreneurship" hreflang="en">Myhal Centre for Engineering Innovation &amp; Entrepreneurship</a></div> <div class="field__item"><a href="/news/tags/banting-best" hreflang="en">Banting &amp; Best</a></div> <div class="field__item"><a href="/news/tags/diabetes" hreflang="en">Diabetes</a></div> <div class="field__item"><a href="/news/tags/frederick-banting" hreflang="en">Frederick Banting</a></div> <div class="field__item"><a href="/news/tags/physiology" hreflang="en">Physiology</a></div> <div class="field__item"><a href="/news/tags/research-innovation" hreflang="en">Research &amp; Innovation</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>One hundred years ago this month, scientists at the University of Toronto and its partner hospitals carried out the first studies that demonstrated the ability of insulin to lower blood sugar levels in animals and prevent their death from diabetes.</p> <p>Three months later, insulin was successfully administered to a person with type 1 diabetes at Toronto General Hospital. His life would become the first of millions around the world to be saved by insulin – one of the landmark medical discoveries of the 20<sup>th</sup> century.</p> <p>On Friday, the historical significance of the discovery was marked by the unveiling of a commemorative bronze plaque at a ceremony hosted by Parks Canada and the Historic Sites and Monuments Board of Canada (HSMBC) at the Myhal Centre for Engineering Innovation &amp; Entrepreneurship on Թϱ’s St. George campus.</p> <p>The event was attended by government dignitaries including Sonia Sidhu, member of parliament for Brampton South. The final location of the plaque, which is inscribed by bilingual text, will be determined at a later date.</p> <p>“The story of insulin is a brilliant example of the power of collaboration – in this case, how a university, its hospital partners and a pharmaceutical company could work together and change the world,” said <b>Christine Allen</b>, Թϱ’s associate vice-president and vice-provost, strategic initiatives.</p> <p>“On this illustrious foundation, Թϱ and its hospital and industry partners built a culture of discovery, innovation and collaboration that has transformed health care and continues to have a ripple effect worldwide.</p> <p><img alt="Patricia Brubaker" class="media-element file-media-original lazy" data-delta="1" height="500" loading="lazy" src="/sites/default/files/2023-04/2021-11-12-Insulin%20Plaque%20Unveiling.%20%287%29-crop.jpg" typeof="foaf:Image" width="750"></p> <p><em>From left: Patricia Brubaker, Richard Alway, Sonia Sidhu, Christine Allen, Christine Loth-Brown and Lynn Wilson (photo by Johnny Guatto)</em></p> <p>The ceremony marked the culmination of <a href="https://insulin100.utoronto.ca/">Insulin 100</a>, a year-long campaign to mark the centenary of insulin’s discovery and celebrate a legacy of health innovation that continues to be advanced by Թϱ and its partner hospitals, research institutes and industry partners.</p> <p>“The Parks Canada plaque not only serves as a fitting reminder of the critical research discoveries made here at Թϱ – it will also inspire future trainees and researchers whose work will be pivotal in the health research discoveries made over the next hundred years,” Allen said.</p> <p><b>Patricia Brubaker</b>, a professor in the departments of physiology and medicine at the Temerty Faculty of Medicine and member of the faculty’s Banting &amp; Best Diabetes Centre, described the key areas of diabetes research being investigated by Թϱ faculty and students today.</p> <p>“Our interests cover the spectrum of diabetes research, including not only type 1 diabetes, but also type 2 diabetes, which is now reaching epidemic levels, affecting one in six Canadians, as well as gestational diabetes or diabetes during pregnancy,” said Brubaker, who has been conducting diabetes research for four decades.</p> <p>“We are studying the causes of diabetes through research into obesity, a major risk factor for type 2 diabetes; we are interrogating new approaches to the treatment of diabetes, including stem cell replacement therapy and new pharmacologic treatments; and our researchers are exploring the fundamental mechanisms that underlie the normal regulation of glucose and fat metabolism and how this is disrupted in diabetes, leading to long-term complications such as kidney and cardiovascular disease.”</p> <p>Brubaker also reflected on the impact of insulin and diabetes research on her own life. As a person living with type 1 diabetes, she noted she is “one of legions who would not be alive today without the discovery of insulin.”</p> <p>In addition to saving countless lives, the discovery of insulin helped establish Թϱ, its partner hospitals and Toronto more generally as a vanguard of diabetes research and treatment.</p> <p>In April, some of the latest developments in the field were <a href="/news/towards-cure-insulin100-scientific-conference-draws-world-s-leading-diabetes-researchers">discussed at the Insulin100 conference</a>, a two-day virtual symposium that drew over 6,000 attendees from around the world.</p> <p>Also in April, Թϱ’s Banting &amp; Best Diabetes Centre and Diabetes Action Canada hosted “100 Years of Insulin – Celebrating its Impact on our Lives,” a public celebration and forum featuring an array of topics of interest to people living with diabetes.</p> <p><img alt="Insulin 100 plaque" class="media-element file-media-original lazy" data-delta="2" height="500" loading="lazy" src="/sites/default/files/2023-04/2021-11-12-Insulin%20Plaque%20Unveiling.%20%2815%29-crop.jpg" typeof="foaf:Image" width="750"></p> <p>It was at this public celebration that <a href="https://insulin100.utoronto.ca/news/commemorative-stamp-marks-100th-anniversary-of-u-of-ts-discovery-of-insulin/">Canada Post unveiled a special stamp</a> to commemorate the discovery of insulin. The stamp, which depicts a vial of insulin resting on an excerpt from Banting’s unpublished memoirs, was unveiled from the Banting House National Historic Site of Canada in London, Ont. – in the very room where Banting first got the idea that eventually led to the discovery of insulin. Brubaker and <b>Scott Heximer</b>, chair of the department of physiology at the Temerty Faculty of Medicine and a principal investigator at the Ted Rogers Centre for Heart Research, worked with Canada Post and Banting House to ensure the stamp’s historical accuracy and help source archival material.</p> <p>The stamp would be the first of several commemorations to mark the place of insulin in the cultural tapestry of Canada’s heritage.</p> <p>In May, Historica Canada released a <a href="https://insulin100.utoronto.ca/news/heritage-minutes-film-showcases-life-saving-impact-of-u-of-ts-insulin-discovery/">Heritage Minutes segment</a> paying tribute to the discovery. The segment depicts the plight of 13-year-old diabetes patient Leonard Thompson, and the efforts of Banting and Best to formulate and refine the insulin treatment that ultimately saves Thompson’s life. Again, experts from Թϱ – including science and medicine librarian <b>Alexandra Carter</b>, archivist <b>Natalya Rattan</b> and medical historian <b>Christopher Rutty</b> – were consulted on the project to ensure historical accuracy.</p> <p>In July, <a href="https://insulin100.utoronto.ca/news/royal-canadian-mint-commemorates-insulin-discovery-at-u-of-t-with-two-dollar-coin/">the Royal Canadian Mint issued its own commemoration</a> in the form of a two-dollar coin depicting a monomer (a building block of the insulin molecule), insulin cells, blood cells, glucose and the scientific instruments used in early formulations of insulin.</p> <p>The importance of insulin was recognized almost immediately after its initial discovery. In 1923, the Nobel Prize in Physiology or Medicine was awarded to <b>Frederick Banting</b> and <b>James McLeod</b>, who isolated insulin in Թϱ’s department of physiology. The prize was shared with physiology and biochemistry student <b>Charles Best</b> and biochemist <b>James Collip</b>.</p> <p>Թϱ researchers continue to be recognized for their stellar work in advancing diabetes research.</p> <p><a href="https://physiology.utoronto.ca/news/professor-patricia-brubaker-wins-diabetes-canada-lifetime-achievement-award">Brubaker was honoured last year with a Lifetime Achievement Award from Diabetes Canada</a>, a recognition of her longstanding contribution to diabetes research and the Canadian diabetes community. And, earlier this year, <b>Daniel Drucker</b>, professor of medicine in the Temerty Faculty of Medicine and a senior investigator at the Lunenfeld-Tanenbaum Research Institute at Sinai Health, <a href="https://insulin100.utoronto.ca/news/u-of-t-scientist-awarded-gairdner-international-award-for-metabolism-research/">was awarded a Canada Gairdner International Award</a> for research on glucagon-like peptides that has helped revolutionize treatments for type 2 diabetes – an honour he shared with collaborators at Harvard University and the University of Copenhagen.</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Fri, 12 Nov 2021 20:15:21 +0000 rahul.kalvapalle 301309 at Commemorative stamp marks 100th anniversary of Թϱ’s discovery of insulin /news/commemorative-stamp-marks-100th-anniversary-u-t-s-discovery-insulin <span class="field field--name-title field--type-string field--label-hidden">Commemorative stamp marks 100th anniversary of Թϱ’s discovery of insulin</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/Insulin%201921-2021%20Stamp%20400P.jpg?h=afdc3185&amp;itok=q0B2QjX8 370w, /sites/default/files/styles/news_banner_740/public/Insulin%201921-2021%20Stamp%20400P.jpg?h=afdc3185&amp;itok=mUT3PPHD 740w, /sites/default/files/styles/news_banner_1110/public/Insulin%201921-2021%20Stamp%20400P.jpg?h=afdc3185&amp;itok=Yg7PJutE 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/Insulin%201921-2021%20Stamp%20400P.jpg?h=afdc3185&amp;itok=q0B2QjX8" alt="&quot;&quot;"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Christopher.Sorensen</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2021-04-15T10:25:09-04:00" title="Thursday, April 15, 2021 - 10:25" class="datetime">Thu, 04/15/2021 - 10:25</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item">Canada Post unveiled the new stamp at an online symposium sponsored by Diabetes Action Canada, Թϱ’s Banting &amp; Best Diabetes Centre and the department of medicine in the Temerty Faculty of Medicine</div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/geoffrey-vendeville" hreflang="en">Geoffrey Vendeville</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/our-community" hreflang="en">Our Community</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/insulin-100" hreflang="en">Insulin 100</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/banting-best" hreflang="en">Banting &amp; Best</a></div> <div class="field__item"><a href="/news/tags/diabetes" hreflang="en">Diabetes</a></div> <div class="field__item"><a href="/news/tags/insulin" hreflang="en">Insulin</a></div> <div class="field__item"><a href="/news/tags/physiology" hreflang="en">Physiology</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Among the treasures in the University of Toronto’s archives are letters from grateful diabetic patients and their families addressed to <b>Frederick Banting</b>, who, along with <b>Charles Best</b>, <b>J. J. R.</b> <b>Macleod</b> and <b>James Collip</b>,<b> </b>discovered the role of insulin in the disease.</p> <p>So, it’s fitting that this year’s celebrations marking the 100th anniversary of the medical breakthrough at Թϱ include a new Canada Post stamp.</p> <p>The stamp, unveiled this week&nbsp;at&nbsp;a virtual celebration held by&nbsp;Diabetes Action Canada, Թϱ’s Banting &amp; Best Diabetes Centre and the department of medicine, features an excerpt from Banting's unpublished memoir and an original insulin bottle with a red cap.</p> <p>Թϱ researchers<b> Scott Heximer</b> and <b>Patricia Brubaker</b> worked with Canada Post and Banting House to ensure the stamp’s historical accuracy and help source archival material.</p> <p>“When we got into this, we didn’t realize everything that went into making a stamp,” says Heximer, an associate professor and chair of the department of physiology in the Temerty Faculty of Medicine.</p> <p>In addition to the stamp itself, the unveiling includes <a href="https://www.canadapost-postescanada.ca/shop/collectors/official-first-day-covers.jsf;CPO_JSESSIONID=LdnLa2wk_RjaQCDynWyVmo1yIycYsZMpIee3_Zq8L65tN-DQ8-cW!549531853?execution=e1s1">an official first day</a> cover that also required fact-checking.</p> <p>“It was fun,” says Heximer. “Our local committee was sitting around looking at pictures of Banting and letters addressed to the doctors in Toronto, and these were all things that went into building this official first day cover.”</p> <p>One hundred years ago, Banting – a surgeon with a struggling practice in London, Ont. and little research experience –&nbsp;approached Macleod in Թϱ’s department of physiology in search of the support and equipment necessary to carry out his experiments. Macleod offered Best, who had recently graduated with a degree in physiology and biochemistry, the opportunity to work with Banting. Together with Collip, a biochemist on sabbatical from the University of Alberta, the researchers succeeded in producing a pancreatic extract from cattle that prevented death from diabetes.</p> <p>Brubaker, a professor in the departments of physiology and medicine, notes that the influence of Banting, Best, Collip and Macleod can still be felt in the department of physiology. For example, she says, Best was chair of the department when Professor Emeritus <b>Mladen Vranic</b> was hired.</p> <p>Vranic, in turn, hired Brubaker, who <a href="https://physiology.utoronto.ca/news/professor-patricia-brubaker-wins-diabetes-canada-lifetime-achievement-award">won a lifetime achievement award from Diabetes Canada last year</a> and <a href="/news/our-very-first-biotech-win-how-u-t-s-discovery-insulin-made-it-research-and-innovation">whose research has contributed to the development of drug treatments for patients with type-2 diabetes</a>. The drugs work by stimulating the secretion of insulin, helping to lower blood sugar levels and reduce appetite, among other effects.</p> <p>In 1923, Banting and Macleod were awarded the Nobel Prize in Physiology or Medicine. Banting was the first Canadian to win a Nobel and remains the youngest winner of the prize in physiology or medicine (he was 32). Banting and Macleod shared the prize with Best and Collip.</p> <p>The discovery of insulin was such a monumental achievement that a stadium full of people listened to Banting discuss the research, according to Brubaker.</p> <p>“It was considered not a cure for diabetes, but a cure for death due to diabetes,” says Brubaker, who lives with type 1 diabetes herself and has devoted much of her career to understanding the disease. “Type 1 diabetes was a death sentence – a slow, prolonged, painful death – and it affected mostly children.”</p> <p>The announcement of a lifesaving treatment was especially welcome news after the end of the First World War and a global pandemic that, like today’s, killed millions.</p> <p>“This was an exciting ray of sunshine,” Brubaker says.</p> <p>In March 1922, <a href="https://www.thestar.com/yourtoronto/once-upon-a-city-archives/2016/01/14/once-upon-a-city-discovering-insulin-was-banting-at-his-best.html?rf">a </a><a href="https://www.thestar.com/yourtoronto/once-upon-a-city-archives/2016/01/14/once-upon-a-city-discovering-insulin-was-banting-at-his-best.html?rf"><i>Toronto Star</i></a><a href="https://www.thestar.com/yourtoronto/once-upon-a-city-archives/2016/01/14/once-upon-a-city-discovering-insulin-was-banting-at-his-best.html?rf"> bold-face headline proclaimed</a>: “Toronto Doctors on Track of Diabetes Cure.”</p> <p>Soon, fan mail poured in for Banting and his colleagues.</p> <p><a href="https://insulin.library.utoronto.ca/islandora/object/insulin%3AP10037">Teddy Ryder</a>, a five-year-old diabetic admitted to hospital weighing just 26 pounds, received his first insulin shots in January 1922. The next year, <a href="https://insulin.library.utoronto.ca/islandora/object/insulin%3AL10021">he wrote a letter to Banting</a> in sprawling capital letters that filled the page. It said: “I wish you could come to see me. I am a fat boy now and I feel fine. I can climb a tree.”</p> <p>Canada has issued stamps since 1851, though most early examples featured English royalty, according to Jim Phillips, director of stamp services at Canada Post. Since then, Leonard Cohen, Alexander Graham Bell and Viola Desmond are among those whose images have graced the tiny squares.</p> <p>As for Banting, he was last featured on a <a href="https://www.arpinphilately.com/itm/canada-stamp-1822a-sir-frederic-banting-insulin-46-2000">Canada Post stamp in 2000</a>.</p> <p>“We see ourselves among the oldest Canadian storytellers,” Phillips said, adding that the discovery of insulin is a “fantastic story” for a stamp.</p> <p>“These are real heroes, these four guys, and the University of Toronto for backing them and giving them space for their research ... This is a very, very positive story –&nbsp;and I think we need positive stories more than ever right now.”</p> <p>&nbsp;</p> <div class="media_embed" height="422px" width="750px"><iframe allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen frameborder="0" height="422px" src="https://www.youtube.com/embed/m4WzO3BYPYs" title="YouTube video player" width="750px"></iframe></div> <p>&nbsp;</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Thu, 15 Apr 2021 14:25:09 +0000 Christopher.Sorensen 169076 at Թϱ scientist receives Gairdner International Award for metabolism research /news/u-t-scientist-receives-gairdner-international-award-metabolism-research <span class="field field--name-title field--type-string field--label-hidden">Թϱ scientist receives Gairdner International Award for metabolism research</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/UofT86637_2020-11-01-Daniel%20Drucker%20%282%29.jpg?h=afdc3185&amp;itok=aF3ApFhl 370w, /sites/default/files/styles/news_banner_740/public/UofT86637_2020-11-01-Daniel%20Drucker%20%282%29.jpg?h=afdc3185&amp;itok=3qBlaZBh 740w, /sites/default/files/styles/news_banner_1110/public/UofT86637_2020-11-01-Daniel%20Drucker%20%282%29.jpg?h=afdc3185&amp;itok=1O-y-Lx6 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/UofT86637_2020-11-01-Daniel%20Drucker%20%282%29.jpg?h=afdc3185&amp;itok=aF3ApFhl" alt="&quot;&quot;"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Christopher.Sorensen</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2021-04-07T15:20:24-04:00" title="Wednesday, April 7, 2021 - 15:20" class="datetime">Wed, 04/07/2021 - 15:20</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item">Թϱ's Daniel Drucker has been jointly awarded the Canada Gairdner International Award for research on glucagon-like peptides – hormones that emanate from the gut to control insulin and glucagon to balance the body's blood sugar (photo by Johnny Guatto)</div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/jim-oldfield" hreflang="en">Jim Oldfield</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/our-community" hreflang="en">Our Community</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/insulin-100" hreflang="en">Insulin 100</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/lunenfeld-tanenbaum-research-institute" hreflang="en">Lunenfeld-Tanenbaum Research Institute</a></div> <div class="field__item"><a href="/news/tags/banting-best" hreflang="en">Banting &amp; Best</a></div> <div class="field__item"><a href="/news/tags/diabetes" hreflang="en">Diabetes</a></div> <div class="field__item"><a href="/news/tags/mount-sinai-hospital" hreflang="en">Mount Sinai Hospital</a></div> <div class="field__item"><a href="/news/tags/research-innovation" hreflang="en">Research &amp; Innovation</a></div> <div class="field__item"><a href="/news/tags/university-health-network" hreflang="en">University Health Network</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>A scientist at the University of Toronto has been jointly awarded a 2021 <a href="https://gairdner.org/">Canada Gairdner International Award</a> for research that has helped revolutionize treatments for type 2 diabetes, obesity and intestinal disorders.</p> <p><b>Daniel Drucker</b> receives the honour with Joel Habener of Harvard University and Massachusetts General Hospital, and Jens Juul Holst of the University of Copenhagen, for research on glucagon-like peptides – hormones that emanate from the gut to control insulin and glucagon, which work in tandem to balance sugar levels throughout the body.</p> <p>The award comes as Թϱ&nbsp;<a href="https://insulin100.utoronto.ca/">celebrates the 100th anniversary of the discovery of insulin</a>, a finding that paved the way for a century of ground-breaking research at the university and its partner hospitals – and just a week before the&nbsp;<a href="https://insulin100.com/">Insulin100 global symposium</a>.</p> <p>“I am extremely excited and honoured that the Gairdner Foundation has recognized our collective work on the glucagon-like peptides, and its translational importance for the treatment of metabolic disorders," said Drucker, a professor in the <a href="https://www.deptmedicine.utoronto.ca/">department of medicine</a> at the <a href="https://medicine.utoronto.ca/">Temerty Faculty of Medicine</a> and a senior scientist at the <a href="https://www.lunenfeld.ca/">Lunenfeld-Tanenbaum Research Institute</a> at Sinai Health.</p> <p>“I am also very grateful for the dozens of contributions made by so many talented trainees that I have been privileged to work with at the University of Toronto.”</p> <p>Working both independently and collaboratively over more than four decades, Holst, Habener and Drucker discovered the peptides known as GLP-1 and GLP-2, detailed their molecular and physiological effects in cells and animals and translated those findings in human studies that have led to several new classes of drugs.</p> <p>Medications based on GLP-1 have begun to significantly improve the care of people living with type 2 diabetes and obesity – conditions that have historically suffered from few or suboptimal treatments. More than 100 million people with type 2 diabetes have been treated with a GLP-1 analogue or a DPP-4 inhibitor, a class of drugs that prevents the breakdown of GLP-1 and GLP-2 and thereby helps improve blood sugar control.</p> <p>Drugs based on GLP-2, meanwhile, can improve nutrient absorption in people with short-bowel syndrome, eliminating the need for intravenous feeding in some patients. And GLP-1-based peptides show promise as cardio-protective agents and in non-alcoholic fatty liver disease and neurodegenerative disorders.</p> <p>“GLP-1 therapies have really advanced our treatment for diabetes and metabolic disorders, and GLP-2 can effectively address a huge unmet need in people with intestinal failure,” said Drucker, who&nbsp;will give an overview of his work at the Insulin100 symposium &nbsp;“Let’s see what more they can do.”</p> <p>The Gairdner Foundation was established in 1957 to recognize fundamental research that impacts human health, bestowing 395 awards to scientists from 35 countries. About a quarter of those recipients have later received Nobel Prizes.</p> <p>The foundation increasingly honours recipients jointly in recognition of the collaborative nature of scientific research and with an eye on human impact, which may only become clear over decades.</p> <p>The scientific journey from the discovery of glucagon-like peptides to their application in several diseases is indeed one of incremental and cumulative change.</p> <p>Holst made the initial observation that patients who had undergone intestinal surgery experienced a rise in insulin followed by a drop in blood sugar after eating – an early sign of links between the gut, sugar levels and the pancreas, which is the main site of insulin and glucagon production.</p> <p>Holst later identified a type of glucagon in blood that originated in the gut but was different from glucagon made in the pancreas.</p> <p>Habener began work around the same time that led to the discovery of glucagon-like peptides. He used pancreatic cells from monkfish to show that glucagon and another hormone were genetically encoded in those cells as larger, precursor hormones.</p> <p>He later found that a precursor called proglucagon included amino acid sequences for two related hormones, and through further work in mammals characterized these peptides – now known as GLP-1 and GLP-2.</p> <p>Drucker joined Habener’s lab as a post-doctoral researcher in the mid-1980s and helped detail the biological function and systemic effects of the peptides. The scientists later observed that gut cells release GLP-1 into the blood in response to food – increasing insulin release in the pancreas and tempering glucagon, and also slowing digestion and decreasing appetite.</p> <p>The results suggested that boosting GLP-1 might improve the glucose-dependent release of insulin in people with type 2 diabetes. Clinical tests by Holst and others confirmed this suspicion and led to drugs known as GLP-1 agonists, now a staple in type 2 diabetes management.</p> <p>Drucker then further detailed the workings of GLP-2, which also arises in the gut as a response to food. He showed, in collaboration with <b>Patricia Brubaker</b> in Թϱ’s <a href="http://www.physiology.utoronto.ca/">department&nbsp;of physiology</a> and department of medicine, that the main role of GLP-2 is to support the growth and health of intestinal cells that enable food absorption. This led to a new treatment for short-bowel syndrome.</p> <p>Drucker also uncovered the workings of GLP-1 in the brain and heart, as well as the circulatory and immune systems, opening new lines of investigation. His work, together with findings from Holst and others, also led directly to the development of dipeptidyl peptidase-4 (DPP-4) inhibitors.</p> <p>Drucker attributes much of his success to a focus on research questions with medical relevance, which he said followed naturally from his education as a physician and may have helped compensate for his relatively scant training in the basic sciences.</p> <p>“Many scientists are better trained, but I’ve always kept one eye on unmet clinical needs and chosen research experiments accordingly,” said Drucker, who counts other clinician-scientists such as Habener – and former Թϱ department of medicine chairs <a href="https://www.bantingresearchfoundation.ca/charles-hollenberg/"><b>Charles Hollenberg</b></a> and <b>Gerard Burrow</b> – as key mentors.</p> <p>Drucker also acknowledges the research contributions of his many trainees and colleagues, as well as some good fortune – including his arrival in Boston just as Habener’s lab <a href="https://uoftmedmagazine.utoronto.ca/2021-winter/#left-turn-right-way">shifted focus from thyroid function to glucagon</a>.</p> <p><b>Gary Lewis</b>, director of the <a href="https://bbdc.org/">Banting and Best Diabetes Centre</a> at Թϱ and a physician-scientist, has known Drucker for three decades and highlights his methodical approach to research.</p> <p>“Dan understands better than most that true scientific advances are a marathon, not a sprint,” said Lewis, who is a professor in the departments of medicine and physiology at the Temerty Faculty of Medicine and an endocrinologist at <a href="https://www.uhn.ca/">University Health Network</a>.</p> <p>“He has contributed decades of careful work, with a precision in controls and other aspects of the experimental process that few have. This is not work that made a quickly forgotten splash in high-profile journals, but it underpins the durable impact for which he is now being rewarded.”</p> <p>Lewis also cites scientific integrity, or the unbiased testing of hypotheses, as key to Drucker’s work.</p> <p>“Too many scientists are enthralled with the ideas behind their hypotheses, but Dan is resolute in letting the data speak.”</p> <p>Lewis said Drucker brings an uncommon work ethic to both his research and pursuits outside the lab – an intensity that has yielded a breadth of knowledge in work with industry on effective treatments for patients.</p> <p>“He is simply one of the greatest scientists this country has ever produced,” he said.</p> <p><b>Trevor Young</b>, dean of Թϱ’s Temerty Faculty of Medicine and a clinician-scientist, said the work by Holst, Habener and Drucker is a classic tale of scientific inquiry that runs from the bedside to the lab bench and back to patients.</p> <p>“I’m reminded of insulin, and the drivers and mechanics of that discovery,” said Young. “This is a story of pursuit and perseverance, but also of measured observation and collaboration at many steps along the way. And it’s changing millions of lives.”</p> <p>&nbsp;</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Wed, 07 Apr 2021 19:20:24 +0000 Christopher.Sorensen 168991 at Diabetes disparities: Թϱ researchers work with communities at risk /news/diabetes-disparities-u-t-researchers-work-communities-risk <span class="field field--name-title field--type-string field--label-hidden">Diabetes disparities: Թϱ researchers work with communities at risk </span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/GettyImages-1286172987.jpg?h=afdc3185&amp;itok=xtwG3HCR 370w, /sites/default/files/styles/news_banner_740/public/GettyImages-1286172987.jpg?h=afdc3185&amp;itok=z_UeyoNa 740w, /sites/default/files/styles/news_banner_1110/public/GettyImages-1286172987.jpg?h=afdc3185&amp;itok=sHXrHFaG 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/GettyImages-1286172987.jpg?h=afdc3185&amp;itok=xtwG3HCR" alt="&quot;&quot;"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>lanthierj</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2021-04-05T08:58:31-04:00" title="Monday, April 5, 2021 - 08:58" class="datetime">Mon, 04/05/2021 - 08:58</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item">(Photo by iStockPhoto/Getty Images)</div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/breaking-research" hreflang="en">Breaking Research</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/insulin-100" hreflang="en">Insulin 100</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/banting-best" hreflang="en">Banting &amp; Best</a></div> <div class="field__item"><a href="/news/tags/dalla-lana-school-public-health" hreflang="en">Dalla Lana School of Public Health</a></div> <div class="field__item"><a href="/news/tags/diabetes" hreflang="en">Diabetes</a></div> <div class="field__item"><a href="/news/tags/indigenous" hreflang="en">Indigenous</a></div> <div class="field__item"><a href="/news/tags/research-innovation" hreflang="en">Research &amp; Innovation</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Rick Bhurji&nbsp;was shocked to learn that, at age 47, he had type 2 diabetes.</p> <p>His next thought was: What did I do wrong?</p> <p>Rick’s daughter, Anjali, noticed that many of their Indo-Canadian friends and family had “mysteriously” developed diabetes. She figured her father’s diabetes was due to his love of pop and junk food.<br> <br> <img class="migrated-asset" src="/sites/default/files/ANANYA-BANERJEE-2020.jpg" alt>“For many of us who are South Asians, we internalize and blame ourselves for the diabetes epidemic in our community, but that is really unfair,” says <strong>Ananya Banerjee</strong>, an assistant professor at the University of Toronto’s Dalla Lana School of Public Health and a researcher with the Temerty Faculty of Medicine’s Banting &amp; Best Diabetes Centre.</p> <p>In fact, people from communities of colour across Canada are at higher risk for diabetes. <a href="https://www.diabetes.ca/resources/tools---resources/communities-of-colour-and-type-2-diabetes">The&nbsp;incidence rate of type 2 diabetes&nbsp;</a>is double in Black communities and triple in South Asian and First Nations communities, compared to white Canadians.</p> <p><a href="https://news.umanitoba.ca/rate-of-children-diagnosed-with-type-2-diabetes-rises-over-50-over-last-10-years-mchp-study-finds/">A&nbsp;recent report&nbsp;found </a>that First Nations children in Manitoba are 25 times more likely to be diagnosed with type 2 diabetes than other children. But disparities in diabetes are about more than ethnicity.</p> <p>Researchers have found that location, income level, education, mental health, and experiences of racism and trauma can all profoundly impact the development and progression of diabetes.</p> <p>By looking beyond basic biology, health-care providers are not only identifying which communities are at risk for diabetes, but also what interventions can make a difference.</p> <p><img class="migrated-asset" src="/sites/default/files/Aisha%20Lofters_photo1%202020.jpg" alt>“In health care, we tend to take a one-size-fits-all approach,” says <strong>Aisha Lofters</strong>, a clinician scientist and an associate professor of family and community medicine at the Temerty Faculty of Medicine.</p> <p>Lofters is also co-leader of&nbsp;<a href="https://better-program.ca/evidence/the-better-wise-project/">the&nbsp;BETTER WISE&nbsp;project </a>which aims to improve the screening and prevention of cancer and chronic illnesses, including diabetes.</p> <p>In practice, set guidelines and flowsheets don’t work for all individuals, explains Lofters.</p> <p>Rather than “wagging the finger” at a patient who, for instance, isn’t meeting the recommended amount of exercise, the BETTER WISE project works with the patient to set individualized, attainable goals –&nbsp;such as going for a 15-minute walk each week.</p> <p>Banerjee took a similar approach with <a href="https://www.canadianjournalofdiabetes.com/article/S1499-2671(19)30475-7/pdf">the South Asian Adolescent Diabetes Awareness Program</a> (SAADAP), providing education and prevention strategies to 80 South Asian teens with a family history of diabetes.</p> <p>Through this pilot program, about eight in 10 participants reduced their intake of sweets and junk food and encouraged their family members to eat healthier.</p> <p>Anjali and Rick, for instance, learned recipes for a healthy mango lassi and chickpea salad that have become staples in their home.<br> <br> Outcomes of tailored diabetes programs are promising&nbsp;but, as obesity management expert and Թϱ alumnus <strong>Sean Wharton</strong>&nbsp;explains, they point to larger flaws in Canada’s health-care system.</p> <p>“Disparity has come about because of a health-care system that isn’t serving people of colour,” says Wharton.</p> <p>Beyond adjusting care to fit individual patient needs, he says some of the most effective ways of treating disparities in diabetes are at the grassroots level, such as in places of worship and community centres.</p> <p>“These are spaces where the people working with the community are not biased against them, and they’re not blaming and shaming them, making them feel unrecognized or discriminated against,” explains Wharton.</p> <p>In an effort to dispel internalized blame or stigma related to diabetes, Banerjee, through SAADAP, highlights the social determinants of health, such as the walkability of neighbourhoods and the burden of precarious employment, and how they affect the participants’ health.</p> <p>Those lessons made Anjali realize, “There’s no need to feel horrible, and that you caused this, because you didn’t.”</p> <p><a href="https://news.umanitoba.ca/rate-of-children-diagnosed-with-type-2-diabetes-rises-over-50-over-last-10-years-mchp-study-finds/">Recent&nbsp;findings from the Manitoba Centre for Health Policy&nbsp;and the First Nations Health and Social Secretariat of Manitoba</a> (FNHSSM) showed that First Nations individuals access primary care at a similar rate to others in the province. However, that care is not reducing complications from type 2 diabetes, such as amputations and kidney failure.</p> <p>“The health system has made it the responsibility of the client with this simplistic idea that if you live healthy, eat healthy and exercise, you’re less likely to have type 2 diabetes. We know there’s more to it than that,” says&nbsp;Lorraine McLeod, associate director of <a href="https://www.fnhssm.com/diabetes-integration-project">the&nbsp;Diabetes Integration Project</a> (DIP), a mobile program that First Nations leaders support to provide on-reserve diabetes care and treatment to more than a dozen First Nations communities in Manitoba.</p> <p>Programs such as the centre’s DIP, B.C.’s&nbsp;<a href="https://bcmj.org/sites/default/files/BCMJ_Vol60_No9_diabetes_First_Nations_BC.pdf">Diabetes and My Nation</a>&nbsp;and <a href="https://mediarelations.uwo.ca/2019/11/04/community-driven-project-improves-patient-outcomes-for-diabetes-in-indigenous-communities/">the cross-Canada&nbsp;FORGE AHEAD&nbsp;program</a> have made significant improvements in diabetes prevention and management by being created by or developed in partnership with First Nations communities.</p> <p>Since the late ’90s in Manitoba, First Nations leaders have been calling for action and collecting the necessary data to address the growing epidemic of diabetes in Indigenous communities.</p> <p>“Oftentimes, research has been led by non-Indigenous researchers who have used their voice and academic lens to analyze Indigenous people, which often leads to continued stigmatization, and upholds the colonial practices and policies that were put in place to assimilate First Nations, Métis and Inuit people into Canadian society,” says&nbsp;Leona Star, the centre’s director of research.</p> <p>As an example of a dataset that accurately identifies First Nations according to their own indicators of well-being, Star points to <a href="https://www.fnhssm.com/copy-of-copy-page-new-2">the national&nbsp;Regional Health Survey </a>(RHS), which she says was “designed and delivered by First Nations with our cultural framework and code of ethics.”</p> <p>According to Star, RHS data has led to federal funding for multiple Indigenous health initiatives, including diabetes prevention. While Star emphasizes the need for First Nations people to govern their own information and data, known as “data sovereignty,” she calls for more action.</p> <p>“It is also important to look at the effectiveness and impacts of research findings,” says Star. “Although significant investments have been made to undertake research around diabetes, the rates of diabetes continue to increase and climb especially amongst First Nations.”</p> <p>While evidence led or co-led by First Nations is available, she says what is lacking are policies and implementation recommendations to address discrimination and disparities in health care.</p> <p>Wharton says the key question is why researchers and health-care providers aren’t acting on what they already know.</p> <p>To address the disparities created by bias, racism and systemic inequalities, he says it’s time that practitioners embrace the strengths of Indigenous peoples and people of colour, rather than assessing how these patients adhere to a system that wasn’t designed for or by them.</p> <p>“We need to shake the foundations of how we help,” he says.&nbsp;</p> <p>This story was originally published in <a href="https://uoftmedmagazine.utoronto.ca/2021-winter/"><em>Թϱ Med Magazine</em>’s Insulin Issue</a>.</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Mon, 05 Apr 2021 12:58:31 +0000 lanthierj 168975 at Insulin 100: How the road to a diabetes cure is yielding better treatments /news/insulin-100-how-road-diabetes-cure-yielding-better-treatments <span class="field field--name-title field--type-string field--label-hidden">Insulin 100: How the road to a diabetes cure is yielding better treatments</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/GettyImages-1282415778.jpg?h=afdc3185&amp;itok=1uwcHIMy 370w, /sites/default/files/styles/news_banner_740/public/GettyImages-1282415778.jpg?h=afdc3185&amp;itok=8Z3pDc4b 740w, /sites/default/files/styles/news_banner_1110/public/GettyImages-1282415778.jpg?h=afdc3185&amp;itok=0zFZK2fE 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/GettyImages-1282415778.jpg?h=afdc3185&amp;itok=1uwcHIMy" alt="&quot;&quot;"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Christopher.Sorensen</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2021-04-01T11:09:30-04:00" title="Thursday, April 1, 2021 - 11:09" class="datetime">Thu, 04/01/2021 - 11:09</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item">(Photo by Getty Images/iStockphoto)</div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/jim-oldfield" hreflang="en">Jim Oldfield</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/our-community" hreflang="en">Our Community</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/institute-biomedical-engineering" hreflang="en">Institute of Biomedical Engineering</a></div> <div class="field__item"><a href="/news/tags/insulin-100" hreflang="en">Insulin 100</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/banting-best" hreflang="en">Banting &amp; Best</a></div> <div class="field__item"><a href="/news/tags/diabetes" hreflang="en">Diabetes</a></div> <div class="field__item"><a href="/news/tags/faculty-applied-science-engineering" hreflang="en">Faculty of Applied Science &amp; Engineering</a></div> <div class="field__item"><a href="/news/tags/insulin" hreflang="en">Insulin</a></div> <div class="field__item"><a href="/news/tags/nutritional-sciences" hreflang="en">Nutritional Sciences</a></div> <div class="field__item"><a href="/news/tags/physiology" hreflang="en">Physiology</a></div> <div class="field__item"><a href="/news/tags/research-innovation" hreflang="en">Research &amp; Innovation</a></div> <div class="field__item"><a href="/news/tags/university-health-network" hreflang="en">University Health Network</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p class="has-black-color" style="margin-bottom:17px">“The pancreas,” says&nbsp;<strong>Gary Lewis</strong>, an endocrinologist at Toronto General Hospital and director of the Banting &amp; Best Diabetes Centre at the University of Toronto’s Temerty Faculty of Medicine, “is like an exquisitely sensitive and perfectly networked computer.”</p> <p class="has-black-color" style="margin-bottom:17px">Second by second,&nbsp;he notes,&nbsp;the pancreas&nbsp;secretes&nbsp;just the right amount of&nbsp;insulin&nbsp;or glucagon&nbsp;to&nbsp;lower or raise&nbsp;blood sugar&nbsp;into&nbsp;the&nbsp;portal vein&nbsp;that leads&nbsp;directly&nbsp;to the liver, the site of key metabolic processes. Insulin is then distributed&nbsp;to every tissue in the body via general circulation.</p> <p class="has-black-color" style="margin-bottom:17px"><img class="migrated-asset" src="/sites/default/files/Lewis%20portrait300.jpg" alt>“Insulin injections are life-saving, but administered under the skin and nowhere near as precise,” says Lewis, who is also a scientist and professor in the department of&nbsp;physiology and <a href="https://www.deptmedicine.utoronto.ca/">department of medicine</a> at Թϱ. “It’s extraordinarily difficult to mimic the function of a healthy pancreas.”</p> <p class="has-black-color" style="margin-bottom:17px">&nbsp;</p> <p class="has-black-color" style="margin-bottom:17px">That’s one reason a cure for diabetes has proven elusive 100 years after the discovery of insulin.</p> <p class="has-black-color" style="margin-bottom:17px">Another big reason is the complexity of how the disease arises. In type 1 diabetes, the immune system destroys the insulin-producing beta cells of the pancreas, creating a life-threatening spike in blood sugar. Type 2 diabetes usually comes on more slowly, as the body becomes resistant to insulin or the pancreas can’t produce enough of it.</p> <p class="has-black-color" style="margin-bottom:17px">Genetics play a role in both types. Exposure to viruses and other environmental effects may be a factor in type 1. Lifestyle factors, including weight gain and physical inactivity, are strongly linked to type 2.</p> <p class="has-black-color" style="margin-bottom:17px">The bottom line, says Lewis, is that diabetes is a multifactoral disease, and we’re not close to a cure.</p> <p class="has-black-color" style="margin-bottom:17px">Ask about treatments, though, and Lewis gets excited.</p> <p class="has-black-color" style="margin-bottom:17px">The last two decades have brought a plethora of clinical and research advances, from new drugs to boost and sensitize the body to insulin and promote weight loss, to lifestyle interventions that improve diet, continuous monitoring of blood sugar, long- and short-lasting insulin, better insulin pumps, pancreatic transplants&nbsp;and pre-clinical stem cell and immunosuppressive therapies.</p> <p class="has-black-color" style="margin-bottom:17px">“Progress on treatments has been fantastic, especially for type 2,” Lewis says. “I’m very, very hopeful.”</p> <p class="has-black-color" style="margin-bottom:17px">The distinction between treatment and cure in medicine is often unclear. And for the 3.6 million Canadians living with diabetes, the distinction matters less and less&nbsp;if the goal is a full and healthy life.</p> <p class="has-black-color" style="margin-bottom:17px">Type 2 diabetes accounts for about 90 per cent of diabetes cases in Canada. Prevalence is rising, but Canadians with type 2 diabetes are living longer and have fewer diabetes-related complications.</p> <p class="has-black-color" style="margin-bottom:17px">“The clinic doesn’t look like it did 30 years ago,” says Lewis, who mainly treats patients with type 2. “We see fewer amputees, less blindness. Patients are generally healthier, and their prognosis is often excellent if they maintain their blood sugar target and other key parameters.”</p> <p class="has-black-color" style="margin-bottom:17px">Weight loss is a cornerstone of treatments to lower blood sugar, and recent research has strengthened the link between weight reduction and type 2 diabetes management. Some people with type 2 can lose weight and control blood sugar through dietary changes and exercise alone.</p> <p class="has-black-color" style="margin-bottom:17px">Bariatric surgery is very effective for weight loss and often results in diabetes remission, although it comes with surgical risks and is expensive.</p> <p class="has-black-color" style="margin-bottom:17px">“If we could prevent obesity, we could greatly reduce the incidence of type 2,” Lewis says. “And experiments have shown we&nbsp;can get a remission with&nbsp;lifestyle changes, so we know what works.”</p> <p class="has-black-color" style="margin-bottom:17px">The problem is broad implementation.</p> <p class="has-black-color" style="margin-bottom:17px">“I’ve tried to lose weight and I know how difficult it can be, especially in an environment of convenient and inexpensive calories,” Lewis says. Moreover, factors such as income, education, ethnicity, access to healthy food and living conditions can make lifestyle changes that curb obesity nearly impossible.</p> <p class="has-black-color" style="margin-bottom:17px">“Social determinants of health are overwhelmingly the most important influence on who gets type 2 diabetes, and how well or poorly they do with it,” Lewis says.</p> <p class="has-black-color" style="margin-bottom:17px">Fortunately, dozens of new drugs for diabetes have hit the market in the last two decades.&nbsp;</p> <p class="has-black-color" style="margin-bottom:17px"><img class="migrated-asset" src="/sites/default/files/jacqueline-beaudry-crop.jpg" alt>Medications for weight loss round out the armamentarium, and some also protect against kidney damage and lower cardiac risk. Current therapies can reduce body weight up to 10 per cent, although a loss of 20 per cent or more would have a greater effect on outcomes for patients with type 2 diabetes, says&nbsp;<strong>Jacqueline Beaudry</strong>, an assistant professor of nutritional sciences at Թϱ who studies links between obesity, hormones and diet.</p> <p class="has-black-color" style="margin-bottom:17px">Beaudry is probing the biology that underpins these medications, including the gut hormones GLP-1 and GIP. They control blood glucose and reduce appetite, but scientists are unsure how.</p> <p class="has-black-color" style="margin-bottom:17px">“If we could understand their mechanisms of action, we could design better drugs,” Beaudry says.</p> <p class="has-black-color" style="margin-bottom:17px">For people with type 1 diabetes, continuous glucose monitors, insulin pumps and even automated “closed-loop”&nbsp;systems that run on mobile apps to deliver insulin as-needed have radically changed the patient experience.</p> <p class="has-black-color" style="margin-bottom:17px"><img class="migrated-asset" src="/sites/default/files/casconcelos-nostro-750x500.jpg" alt></p> <p><span id="cke_bm_372S" style="display: none;">&nbsp;</span><em>Sara Vasconcelos left),&nbsp;an assistant professor at Թϱ’s Institute of Biomedical Engineering, has worked with&nbsp;<strong>Cristina Nostro </strong>(right), an associate professor in the department of physiology,<strong>&nbsp;</strong>and her team in the McEwen Stem Cell Institute at UHN&nbsp;to extend the survival and functionality of pancreatic precursor cells generated&nbsp;from human stem cells.&nbsp;</em></p> <p class="has-black-color" style="margin-bottom:17px">Cell therapy could prove more liberating still.<br> <br> University labs and biotechs are working on implantable devices that house insulin-producing cells derived from stem cells.</p> <p class="has-black-color" style="margin-bottom:17px">To that end,&nbsp;<strong>Cristina Nostro</strong>, an associate professor in the department of physiology in the Temerty Faculty of Medicine,<strong>&nbsp;</strong>and her team in the McEwen Stem Cell Institute at University Health Network recently discovered a more efficient way to generate and purify pancreatic precursor cells from human stem cells in the lab.</p> <p class="has-black-color" style="margin-bottom:17px">They have also found a way to vascularize those cells by working with&nbsp;<strong>Sara Vasconcelos</strong>, an assistant professor at Թϱ’s Institute of Biomedical Engineering. Together, they have extended the survival and functionality of the cells in animal models of diabetes.</p> <p class="has-black-color" style="margin-bottom:17px">The biggest problem with these therapies is that the immune system rejects them. The same challenge currently hinders pancreas and islet transplants.&nbsp;</p> <p class="has-black-color" style="margin-bottom:17px">“The immune system is an amazing machine, we’re lucky&nbsp;it’s so good,” says Nostro. “But it’s very difficult to control when it goes awry, as in autoimmune conditions.”</p> <p class="has-black-color" style="margin-bottom:17px">Nostro is working with immunologists at the university on a method to protect insulin-producing beta cells from immune rejection, and she says many researchers in the field are now focused on immune-protective approaches.</p> <p class="has-black-color" style="margin-bottom:17px">Another strategy for type 1 diabetes is to tamp down the autoimmune response before the disease progresses. The idea is to prevent immune cells that damage the pancreas while the body still produces beta cells.</p> <p class="has-black-color">“Groups around the world are bringing different ideas and creative approaches to treat type 1 diabetes, that’s the beauty of science,” says Nostro. “I am very hopeful about what the future holds. Who knows? Maybe we will see hybrid technologies combining a pump and cells. We have to keep an open mind.”</p> <p class="has-black-color"><i>This story was originally published in Թϱ Med Magazine’s </i><a href="https://uoftmedmagazine.utoronto.ca/2021-winter/"><i>Insulin Issue</i></a><i>.</i></p> <p class="has-black-color" style="margin-bottom:17px">&nbsp;</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Thu, 01 Apr 2021 15:09:30 +0000 Christopher.Sorensen 168957 at Event to mark 100th anniversary of Թϱ's discovery of insulin and map future of diabetes care /news/u-t-event-mark-100th-anniversary-insulin-s-discovery-and-map-future-diabetes-care <span class="field field--name-title field--type-string field--label-hidden">Event to mark 100th anniversary of Թϱ's discovery of insulin and map future of diabetes care</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/GettyImages-1130140623.jpg?h=afdc3185&amp;itok=5jwwcXW5 370w, /sites/default/files/styles/news_banner_740/public/GettyImages-1130140623.jpg?h=afdc3185&amp;itok=In0OzrUX 740w, /sites/default/files/styles/news_banner_1110/public/GettyImages-1130140623.jpg?h=afdc3185&amp;itok=u4TDRosm 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/GettyImages-1130140623.jpg?h=afdc3185&amp;itok=5jwwcXW5" alt="A vial of insulin on a table"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Christopher.Sorensen</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2021-03-26T09:21:31-04:00" title="Friday, March 26, 2021 - 09:21" class="datetime">Fri, 03/26/2021 - 09:21</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item">(Photo by Samara Heisz/Getty Images)</div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/jim-oldfield" hreflang="en">Jim Oldfield</a></div> <div class="field__item"><a href="/news/authors-reporters/krista-lamb" hreflang="en">Krista Lamb</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/global-lens" hreflang="en">Global Lens</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/insulin-100" hreflang="en">Insulin 100</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/banting-best" hreflang="en">Banting &amp; Best</a></div> <div class="field__item"><a href="/news/tags/diabetes" hreflang="en">Diabetes</a></div> <div class="field__item"><a href="/news/tags/mount-sinai-hospital" hreflang="en">Mount Sinai Hospital</a></div> <div class="field__item"><a href="/news/tags/research-innovation" hreflang="en">Research &amp; Innovation</a></div> <div class="field__item"><a href="/news/tags/sir-frederick-banting" hreflang="en">Sir Frederick Banting</a></div> <div class="field__item"><a href="/news/tags/st-michael-s-hospital" hreflang="en">St. Michael's Hospital</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The University of Toronto will co-host a public celebration this spring on the impact of insulin, one of several&nbsp;<a href="https://insulin100.utoronto.ca/">Insulin100&nbsp;events</a> that will mark the centenary year of a discovery that has saved the lives of millions of people.</p> <p>On April 14,&nbsp;<a href="https://insulin100.utoronto.ca/event/100-years-of-insulin-celebrating-its-impact-on-our-lives/">100 Years of Insulin: Celebrating Its Impact on Our Lives</a>&nbsp;will feature researchers sharing developments in diabetes care&nbsp;and people with diabetes who are&nbsp;patient partners with&nbsp;<a href="https://diabetesaction.ca">Diabetes Action Canada</a>.</p> <p><strong><img class="migrated-asset" src="/sites/default/files/Perkins_Bruce.jpg" alt>Bruce Perkins</strong>,&nbsp;a diabetes researcher who lives with type 1 diabetes, will speak about the rapid evolution of treatments, including insulin pumps, continuous glucose monitors, islet transplants and stem cells.</p> <p>“It is humbling to realize what an extraordinary thing this discovery was 100 years ago, and that we’re so fortunate to be able to celebrate it in its fullest,” said Perkins, a professor in Թϱ’s Temerty Faculty of Medicine and director of the&nbsp;<a href="https://www.mountsinai.on.ca/care/lscd/leadership-sinai-centre-for-diabetes">Leadership Sinai Diabetes Centre</a>&nbsp;at Sinai Health. “The history really motivates me. It was a simple discovery with so much impact.”</p> <p>Diabetes Action Canada&nbsp;will present the event in collaboration with the&nbsp;<a href="https://bbdc.org">Banting &amp; Best Diabetes Centre</a>&nbsp;(BBDC) at Թϱ and the Temerty Faculty of Medicine’s&nbsp;<a href="https://www.deptmedicine.utoronto.ca">department of medicine</a>. The <a href="https://research.utoronto.ca/">Division of the Vice-President, Research and Innovation</a> at Թϱ will also support the event along with Diabetes Canada and the JDRF Canada, a non-profit focused on type 1 diabetes research and advocacy.</p> <p>Grant Maltman, curator at the Banting House National Historic Site of Canada, will recount <strong>Frederick Banting</strong>’s middle-of-the-night moment that changed history. He will also unveil a Canada Post stamp commemorating the 100th anniversary of the discovery.</p> <p><strong><img class="migrated-asset" src="/sites/default/files/CHENG%202017%20A.jpg" alt>Alice Cheng,&nbsp;</strong>an associate professor in Temerty Medicine’s department of medicine&nbsp;and an endocrinologist at Trillium Health Partners and Unity Health Toronto, will co-host a panel on diabetes treatments.&nbsp;</p> <p>“It’s exciting to learn from the past&nbsp;in terms of understanding the history of the discovery, and then learn about what’s happening now and what might happen in the future,” Cheng said. “It is a celebration of the achievement, but also meant to further inspire everyone to continue this work so things keep getting better. It’s a very proud moment.”</p> <p>People living with diabetes will be front and centre at the event. They include:</p> <ul> <li>Mike Alexander, an Anishinaabe artist and athlete who has struggled with depression and addiction. He is a Sixties Scoop survivor and recently became a member of Diabetes Action Canada’s Indigenous Patient Circle.</li> <li>Chloe Pow, who was diagnosed with diabetes at the age of four. She has become an advocate for people living with diabetes and, together with her father&nbsp;Conrad Pow,&nbsp;provides volunteer peer-support for other children who have been recently diagnosed.</li> <li>Jen Hanson, the executive director of the non-profit Connected in Motion. She has lived with type 1 diabetes for more than 30 years and will share ways to lead an active and healthy life.</li> </ul> <p>As well, researchers from across Canada will explain how people living with diabetes have begun playing an active and vital role in research studies.</p> <p>“When we started to explore how to celebrate this milestone, we knew that people living with diabetes needed to be at the heart of it,” said&nbsp;<strong>Gary Lewis</strong>, director of the BBDC and scientific co-lead for Diabetes Action Canada.</p> <p>“We are so thrilled to have an array of speakers who will be sharing their experiences in a way that will educate and inspire,” said Lewis, who is a professor in the department of medicine in the Temerty Faculty of Medicine.</p> <p>“Our greatest hope is that a cure will happen within the next 100 years, but for now we want to show our appreciation for this life-saving discovery.”</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Fri, 26 Mar 2021 13:21:31 +0000 Christopher.Sorensen 168880 at 'The future Bantings and Bests': How insulin's discovery at Թϱ is fuelling research 100 years later /news/future-bantings-and-bests-how-insulin-s-discovery-u-t-fuelling-research-100-years-later <span class="field field--name-title field--type-string field--label-hidden">'The future Bantings and Bests': How insulin's discovery at Թϱ is fuelling research 100 years later</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/GettyImages-924527484.jpg?h=afdc3185&amp;itok=sYO-xVdh 370w, /sites/default/files/styles/news_banner_740/public/GettyImages-924527484.jpg?h=afdc3185&amp;itok=TBkssfJR 740w, /sites/default/files/styles/news_banner_1110/public/GettyImages-924527484.jpg?h=afdc3185&amp;itok=n7V8wNOY 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/GettyImages-924527484.jpg?h=afdc3185&amp;itok=sYO-xVdh" alt="&quot;&quot;"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Christopher.Sorensen</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2021-03-19T11:44:14-04:00" title="Friday, March 19, 2021 - 11:44" class="datetime">Fri, 03/19/2021 - 11:44</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item">Թϱ's Janet Rossant, pictured here in her SickKids lab, says a $25,000 grant from the Banting Research Foundation was a key moment early in her career (photo by Richard Lautens/Toronto Star via Getty Images)</div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/paul-fraumeni" hreflang="en">Paul Fraumeni</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/our-community" hreflang="en">Our Community</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/insulin-100" hreflang="en">Insulin 100</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/donnelly-centre-cellular-biomolecular-research" hreflang="en">Donnelly Centre for Cellular &amp; Biomolecular Research</a></div> <div class="field__item"><a href="/news/tags/banting-best" hreflang="en">Banting &amp; Best</a></div> <div class="field__item"><a href="/news/tags/biochemistry" hreflang="en">Biochemistry</a></div> <div class="field__item"><a href="/news/tags/hospital-sick-children" hreflang="en">Hospital for Sick Children</a></div> <div class="field__item"><a href="/news/tags/insulin" hreflang="en">Insulin</a></div> <div class="field__item"><a href="/news/tags/molecular-genetics" hreflang="en">Molecular Genetics</a></div> <div class="field__item"><a href="/news/tags/research-innovation" hreflang="en">Research &amp; Innovation</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>It was 1983 and&nbsp;<strong>Janet Rossant</strong>&nbsp;was 33 years old.&nbsp;</p> <p>Six years earlier, she left her native England with degrees from Oxford and Cambridge. She had landed a position at Brock University in St. Catharines, Ont.&nbsp;– across the lake from Toronto. &nbsp;</p> <p>Then an assistant professor of biology, Rossant headed a laboratory team seeking to understand how the embryo develops. To do that, the Rossant team was starting to develop transgenic mice.&nbsp;&nbsp;</p> <p>“This was a new field of developmental biology, and we were excited by the possibility of being able to add genes to embryos and study their effect on development. But to do this research, we needed specialized equipment and we also needed the money to buy it,” says Rossant, who has been a researcher at the University of Toronto for the past 36 years.</p> <p>So, Rossant applied to the Banting Research Foundation (BRF), which awarded her $25,000 – not a huge amount, but an important influx of financing for a researcher who was starting to build a track record.&nbsp;&nbsp;</p> <p>“People like to talk about the tipping point,” she says. “When you’re a young investigator and you don’t have a lot of funding, it’s hard to move to the next level. So, the Banting Foundation was then, and&nbsp;still is, a really important support for new investigators, providing that critical piece of funding just when you need it.”</p> <p>That early support paid off for Rossant – and for global society.&nbsp;&nbsp;</p> <p>By 1985, Rossant had moved to Թϱ&nbsp;and the Samuel Lunenfeld Research Institute (known today as the Lunenfeld-Tanenbaum Research Institute) at Mount Sinai Hospital.<br> <br> Over the next 30 years, Rossant&nbsp;conducted research&nbsp;on genetics and stem cells that earned her renown and a bevy of awards. Today, Rossant is a&nbsp;<a href="https://www.provost.utoronto.ca/awards-funding/university-professors/">University Professor</a>&nbsp;in the department of molecular genetics at the Temerty Faculty of Medicine, a senior scientist and chief of research emeritus at the Hospital for Sick Children and&nbsp;the president and scientific director of the Gairdner Foundation.</p> <p>It’s an impressive&nbsp;career arc that, in many ways, can be traced to the discovery of insulin at Թϱ decades earlier.</p> <p>In 1921, sixty-three years before Rossant applied for that $25,000 fateful grant, an unlikely team was hard at work in a Թϱ lab on a disease – diabetes – that had killed millions over the centuries and continued to bewilder scientists.&nbsp;&nbsp;</p> <p><strong>Frederick Banting</strong>, a physician with little research experience, and <strong>Charles Best</strong>, a medical student, were investigating Banting’s plan&nbsp;to isolate the mysterious secretion of the pancreas that controlled metabolism.&nbsp;&nbsp;</p> <p><strong>J.J.R. Macleod</strong>, then Թϱ’s chair of physiology, somewhat reluctantly gave the team lab space, equipment and dogs to use for testing.&nbsp;&nbsp;</p> <p>Banting’s idea worked.&nbsp;</p> <p>The discovery won the Nobel Prize in 1923 and continues to enable people with type 1 diabetes to live full, rich lives –&nbsp;once an&nbsp;unthinkable outcome.&nbsp;But the legacy of insulin’s discovery goes well beyond diabetes by acting as a&nbsp;catalyst to stimulate a century of medical research in a dizzying array of areas.<br> <br> For one thing,&nbsp;two research-supporting foundations were established in the spirit of Banting and Best, including the BRF.&nbsp;</p> <p>“Our mission is to fund young investigators, the future Bantings and Bests, in the way they were funded by Macleod, at the beginnings of their careers when they have a bold idea that just might move society forward,” says&nbsp;<strong>Catharine Whiteside</strong>, BRF chair, former dean of medicine and an emerita professor with the department of medicine.&nbsp;</p> <p>In 1960, W. Garfield Weston Foundation funding established the Dr. Charles H. Best Foundation. The original idea was to support research at the discretion of Best, who went on to conduct important studies in a number of areas and become a Թϱ research leader.&nbsp;&nbsp;</p> <p>When Best retired in 1965, the funds were designated to Թϱ’s Banting and Best department of medical research. That unit later became part of the Donnelly Centre for Cellular and Biomolecular Research.</p> <p>“Today, those funds are used to support researchers getting started on their careers through a program called the Dr. Charles H. Best Postdoctoral Fellows,” says&nbsp;<strong>Peter Lewis</strong>, the program’s board chair and former chair of the department of biochemistry at Թϱ. “This funding enables us to help researchers of a high calibre from around the world to pursue their ideas and to learn with the scientists of the Donnelly.”</p> <p>These two foundations have helped launch&nbsp;remarkable careers.&nbsp;&nbsp;</p> <p>“The influence of Banting and Best goes way beyond diabetes and insulin,” says Professor&nbsp;<strong>Reinhart Reithmeier</strong>, also a former chair of the department of biochemistry who was a winner of a Best Postdoctoral Fellowship&nbsp;in the late 1970s.&nbsp;&nbsp;</p> <p>The Toronto insulin discovery continues to ignite important ideas from newer generations.&nbsp;&nbsp;</p> <p>At the Donnelly Centre, the 2019 Best Postdoctoral Fellow&nbsp;<strong>Juline Poirson</strong>&nbsp;is studying the ubiquitin-proteasome system (UPS). It is critical in ensuring the normal functioning of cells, notably by destroying proteins that are no longer needed. But in diseases such as cancer, the UPS is dysregulated.&nbsp;</p> <p>Poirson is working to understand why this happens with certain proteins. Her work could lead to important drug developments to treat diseases like cancer.&nbsp;</p> <p>“I came from France to the Donnelly because I knew it would help me build on what I had already learned,” she says. “It is one of the best research centres in the world when you work on protein-protein interaction. This experience is going to help me for the rest of my career.”&nbsp;</p> <p><strong>Nomazulu Dlamini</strong>&nbsp;is an associate professor of pediatrics in the Temerty Faculty of Medicine and a staff physician at SickKids Hospital. The pediatric neurologist and scientist specializes in understanding and treating strokes in children.&nbsp;Her focus is dystonia, a disabling and painful disorder that can occur in children who have experienced a stroke. It’s characterized by involuntary, repetitive muscle contractions, twisting movements and abnormal posturing. Often, it is resistant to treatment.&nbsp;&nbsp;</p> <p>It is thought that the problem originates in the basal ganglia, a network in the brain. Dlamini’s lab is studying the differences in the neural network between childhood stroke patients who have dystonia and those who don’t. Understanding why some children experience dystonia will increase the potential of developing effective therapies.</p> <p>The BRF awarded Dlamini $25,000 in 2018 to support her work in understanding dystonia.&nbsp;</p> <p>“That support has been very helpful. With the pilot data from the work we have been able to get because of the Banting funding, we’ve been able to leverage that for further funding,” says Dlamini.</p> <p>“That’s all because Banting believed in our idea of discovering why there is this difference between these two groups of children.”</p> <p><em>This story, which has been edited and condensed, was originally published in Թϱ Med Magazine’s </em><a href="https://uoftmedmagazine.utoronto.ca/2021-winter/"><em>Insulin Issue</em></a><em>.</em><br> &nbsp;</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Fri, 19 Mar 2021 15:44:14 +0000 Christopher.Sorensen 168795 at PBS Newshour commemorates Թϱ’s Charles Best, of insulin fame /news/pbs-newshour-commemorates-u-t-s-charles-best-insulin-fame <span class="field field--name-title field--type-string field--label-hidden">PBS Newshour commemorates Թϱ’s Charles Best, of insulin fame</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/GettyImages-2638358-crop.jpg?h=afdc3185&amp;itok=INihNulP 370w, /sites/default/files/styles/news_banner_740/public/GettyImages-2638358-crop.jpg?h=afdc3185&amp;itok=kFQ33ycA 740w, /sites/default/files/styles/news_banner_1110/public/GettyImages-2638358-crop.jpg?h=afdc3185&amp;itok=_0x_z6pI 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/GettyImages-2638358-crop.jpg?h=afdc3185&amp;itok=INihNulP" alt="&quot;&quot;"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>wangyana</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2021-03-05T15:35:24-05:00" title="Friday, March 5, 2021 - 15:35" class="datetime">Fri, 03/05/2021 - 15:35</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item">(Photo by Keystone-France/Gamma-Keystone via Getty Images)</div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/global-lens" hreflang="en">Global Lens</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/insulin-100" hreflang="en">Insulin 100</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/banting-best" hreflang="en">Banting &amp; Best</a></div> <div class="field__item"><a href="/news/tags/biochemistry" hreflang="en">Biochemistry</a></div> <div class="field__item"><a href="/news/tags/charles-best" hreflang="en">Charles Best</a></div> <div class="field__item"><a href="/news/tags/frederick-banting" hreflang="en">Frederick Banting</a></div> <div class="field__item"><a href="/news/tags/insulin" hreflang="en">Insulin</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The life of University of Toronto’s <strong>Charles Best,</strong> who helped discover insulin, was recently commemorated in a&nbsp;<em><a href="https://www.pbs.org/newshour/health/how-a-medical-student-helped-discover-lifesaving-insulin">PBS Newshour column</a></em> in honour of Best’s birthday last month.</p> <p>The piece recounts the story of how a winning coin toss gave Best the opportunity to work with Ontario surgeon <strong>Frederick Banting</strong> in a Թϱ laboratory. Best was only 21 years old and still a&nbsp;student at Թϱ at the time.</p> <p>“The entire hot, sticky summer of 1921, Banting and Best toiled in a tiny, smelly laboratory, gathering their data,” <em>PBS Newshour </em>writes.</p> <p>With the help of two other scientists, Թϱ graduate <strong>James Collip </strong>and <strong>J.J.R. Macleod</strong>, a Թϱ professor of biochemistry, Banting and Best isolated the pancreatic hormone, now known as insulin, that paved the way to lifesaving treatments for diabetes patients around the world, the column says.</p> <p>It goes on to detail how, in 1922, a 14-year-old boy with end-stage juvenile diabetes became the first human to be treated with – and eventually saved by – insulin. While only Banting and Macleod were awarded the 1923 Nobel Prize in Medicine&nbsp;for the breakthrough,&nbsp;the column notes that Banting and Macleod shared their prize money with Best and Collip.</p> <p>Insulin became “one of the most successful drugs of the 20th century,” <em>PBS Newshour </em>says.</p> <h3><a href="https://www.pbs.org/newshour/health/how-a-medical-student-helped-discover-lifesaving-insulin">Read more about Charles Best in <em>PBS Newshour</em></a></h3> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Fri, 05 Mar 2021 20:35:24 +0000 wangyana 168632 at ‘Our very first biotech win’: How Թϱ’s discovery of insulin made it a research and innovation powerhouse /news/our-very-first-biotech-win-how-u-t-s-discovery-insulin-made-it-research-and-innovation <span class="field field--name-title field--type-string field--label-hidden">‘Our very first biotech win’: How Թϱ’s discovery of insulin made it a research and innovation powerhouse</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2020-10-28-Patricia%20Brubaker%20%281%29.jpg?h=afdc3185&amp;itok=hWq56nrN 370w, /sites/default/files/styles/news_banner_740/public/2020-10-28-Patricia%20Brubaker%20%281%29.jpg?h=afdc3185&amp;itok=_7E95kZX 740w, /sites/default/files/styles/news_banner_1110/public/2020-10-28-Patricia%20Brubaker%20%281%29.jpg?h=afdc3185&amp;itok=vLaVyWLn 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2020-10-28-Patricia%20Brubaker%20%281%29.jpg?h=afdc3185&amp;itok=hWq56nrN" alt="&quot;&quot;"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>rahul.kalvapalle</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2020-11-04T12:05:12-05:00" title="Wednesday, November 4, 2020 - 12:05" class="datetime">Wed, 11/04/2020 - 12:05</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item">Թϱ's Patricia Brubaker, who has spent nearly 40 years studying anti-diabetic gut hormones, says the future of diabetes research will be figuring out how to prevent the disease in the first place (photo by Johnny Guatto)</div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/rahul-kalvapalle" hreflang="en">Rahul Kalvapalle</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/our-community" hreflang="en">Our Community</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/institute-biomedical-engineering" hreflang="en">Institute of Biomedical Engineering</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/banting-best" hreflang="en">Banting &amp; Best</a></div> <div class="field__item"><a href="/news/tags/diabetes" hreflang="en">Diabetes</a></div> <div class="field__item"><a href="/news/tags/entrepreneneurship" hreflang="en">Entrepreneneurship</a></div> <div class="field__item"><a href="/news/tags/faculty-applied-science-engineering" hreflang="en">Faculty of Applied Science &amp; Engineering</a></div> <div class="field__item"><a href="/news/tags/health-innovation-hub" hreflang="en">Health Innovation Hub</a></div> <div class="field__item"><a href="/news/tags/insulin" hreflang="en">Insulin</a></div> <div class="field__item"><a href="/news/tags/research-innovation" hreflang="en">Research &amp; Innovation</a></div> <div class="field__item"><a href="/news/tags/royal-society-canada" hreflang="en">Royal Society of Canada</a></div> <div class="field__item"><a href="/news/tags/startups" hreflang="en">Startups</a></div> <div class="field__item"><a href="/news/tags/ted-rogers-centre-heart-research" hreflang="en">Ted Rogers Centre for Heart Research</a></div> <div class="field__item"><a href="/news/tags/ted-sargent" hreflang="en">Ted Sargent</a></div> <div class="field__item"><a href="/news/tags/thisistheplace" hreflang="en">ThisIsThePlace</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>For nearly four decades, <strong>Patricia Brubaker</strong> has been investigating the biological activities of anti-diabetic gut hormones secreted by the intestine.</p> <p>Her work is focused on the fundamental biology of the hormones and has contributed to development of drugs for the treatment of patients with Type 2 diabetes. The drugs work by stimulating the secretion of insulin, helping to lower blood sugar levels and reducing appetite, among other effects.</p> <p>Brubaker understands all too well the impact such research has had on people’s lives – she is a Type 1 diabetes patient herself.</p> <p>“The progress over the last 40 years has been simply phenomenal in terms of how people with diabetes are treated clinically, the extension of their life spans and the prevention of complications,” says Brubaker, a professor in the departments of physiology and medicine in the University of Toronto’s Temerty Faculty of Medicine and a member of the faculty’s Banting &amp; Best Diabetes Centre.</p> <p>Brubaker, a fellow of the Royal Society of Canada who recently <a href="https://physiology.utoronto.ca/news/professor-patricia-brubaker-wins-diabetes-canada-lifetime-achievement-award">won a lifetime achievement award from Diabetes Canada</a>, says huge strides are being made in the treatment of the disease, which affects as many as one out of three Canadians when the condition known as prediabetes is taken into account.</p> <p>But she stresses that research on prevention is equally crucial.</p> <p>“What we need to do is figure out how we can prevent diabetes in the first place,” she says.</p> <p>“Diabetes prevention science is going to be all about how we can predict the onset of diabetes, which is great. But if we know someone’s going to develop diabetes, how do we prevent it? That’s still an area of intense investigation.”</p> <p>These and other pressing questions on the future of diabetes treatment and prevention science will be addressed by Brubaker and other experts at a Nov. 26 panel discussion that’s part of a virtual symposium examining the impact of the discovery of insulin by Թϱ’s <strong>Frederick Banting</strong> and <strong>Charles Best</strong>, who worked with <strong>J.J.R Macleod</strong> and <strong>James Collip</strong>. <a href="https://rsc-src.ca/sites/default/files/UofT_Insulin100_Programme_EN_2020_0.pdf">“The Legacy of Insulin Discovery: Origins, Access, and Translation”</a> will examine insulin and diabetes from a range of perspectives, including laboratory research, clinical practice, pharmacy, commercialization, entrepreneurship, digital technology and socio-economic factors.</p> <p>It’s the first in a series of events organized by Թϱ to commemorate the 100<sup>th</sup> anniversary of the discovery of insulin, and one of the highlights of the <a href="https://rsc-src.ca/en/events/coee2020">2020 Celebration of Excellence and Engagement</a>, a week-long exploration of scholarly, scientific and artistic topics presented by Թϱ and the Royal Society of Canada.</p> <h3><a href="https://www.eventbrite.ca/e/insulin-the-legacy-of-insulin-discovery-origins-access-and-translation-tickets-125202404763">Learn more about the Nov. 26 insulin symposium</a></h3> <p><img class="migrated-asset" src="/sites/default/files/insulin_P10077_0001-crop.jpg" alt>“The discovery of insulin by <strong>Frederick Banting </strong>and <strong>Charles Best</strong>, and their team, is a testament to what we can achieve when we empower scientific research and find ways to share it with the world,” says <a href="https://www.provost.utoronto.ca/awards-funding/university-professors/">University Professor</a> <strong>Ted Sargent</strong>, Թϱ’s vice-president, research and innovation, and strategic initiatives.</p> <p>&nbsp;</p> <p>“That extraordinary work done in the early 1920s not only saved millions of lives, it laid the foundation for the University of Toronto’s world-class student training programs and robust partnerships with hospitals and industry – collaborations that continue to revolutionize health care today.”</p> <p>Brubaker says collaborations have been crucial in her research career. Recently, she’s partnered with researchers who study gut bacteria, which appears to play a role in the production of the gut hormones that she studies: GLP-1 and GLP-2.</p> <h3><a href="/news/u-t-s-daniel-drucker-celebrated-diabetes-research-remarkable-global-impact">Read more about Թϱ researchers whose gut hormone work advanced diabetes care</a></h3> <p>She says our improved understanding of GLP-1 has led to the development of drugs that can mimic the actions of the hormone, which is naturally secreted by the intestine and helps produce more insulin to keep blood sugar levels in check. It has also led to the advent of DPP-4 inhibitors, a class of prescription medicines that slow the inactivation and degradation of GLP-1, making it last longer in the body.</p> <p>“The long-term goal is that, if we can promote higher release of GLP-1 into the bloodstream and then maybe combine that with the DPP-4 inhibitors, we might end up with a better combination therapy,” Brubaker says.</p> <p>Her lab has also been exploring ways to take advantage of the relatively recent finding that release of GLP-1 is time-dependent and influenced by the body’s circadian rhythms.</p> <p>“GLP-1 is actually secreted at higher levels during different times of the day,” she says.</p> <p>“Our notion is that maybe we can take advantage of these natural rhythms to help promote release of GLP-1 when our body needs it, and not promote release when our body doesn’t need it.”</p> <p>Brubaker identifies stem cell therapy and the development of smarter forms of insulin that don’t cause patients’ blood glucose to drop to unsafe levels as other promising avenues of diabetes research.</p> <p>Yet, when it comes to preventing and treating diabetes, novel research is only one piece of the puzzle.</p> <p><strong>Paul Santerre</strong>, a professor in the Faculty of Dentistry and the Institute of Biomedical Engineering, says the extent of progress on diabetes and insulin will partly depend on how well research breakthroughs from scholars like Brubaker can be married with efforts at commercialization and innovation.</p> <p>He notes that the discovery of insulin and its subsequent development and commercialization transformed the lives of millions of people around the world – and offers lessons that are still applicable today.</p> <p>“When you contemplate the past 100 years, insulin was probably our very first biotech win that didn’t only do the lab work but also executed on the translational aspect – and did it way before Canada and the investor community knew what they held in their hands,” says Santerre, who is cross-appointed to the department of chemical engineering and applied chemistry and the Temerty Faculty of Medicine via his health research at the Ted Rogers Centre for Heart Research.</p> <p>He says that while home-grown Canadian commercialization successes in health care could be measured with one or two wins per decade since the success of insulin’s commercialization, a second wind of research commercialization began to blow through the life sciences in Canada in the early 1990s.</p> <p>“Since my arrival at Թϱ in 1993, I’ve seen activity in the life sciences innovation sector grow quadratically. The future looks extremely bright and the growth is completely on the right path and must be sustained.”</p> <p>Santerre will reflect on this growth and the path forward during a panel discussion on commercialization and innovation at the Nov. 26 symposium.</p> <p>“If we have an innovation agenda and support it in parallel with the discovery programs at the university, we can teach our students about how to do innovation, scale up a technology and introduce it to world markets in a cost-effective manner that the health-care system can afford,” Santerre says. “We will end up with a generation that truly has the ability to execute on discoveries coming out of our university.”</p> <p>He adds that the introduction and expansion of campus-linked accelerators at universities like Թϱ has sparked a shift in thinking on campus.</p> <p>“It’s very different to the way I was trained in the 1980s, and it’s very refreshing to see the innovation economy – certainly as it pertains to health sciences – start to become mainstream here in Canada,” he says.</p> <p><img class="migrated-asset" src="/sites/default/files/SanterreP-UofT-Dentistry-IBBME-02-20170511-crop.jpg" alt></p> <p><em>Paul Santerre, a professor in the Faculty of Dentistry and the Institute of Biomedical Engineering, says Canada’s “innovation economy” is on a roll, with Toronto now attracting life sciences talent from across Canada and around the world (photo by Luke Ng)</em></p> <p>As co-founder and director of the Health Innovation Hub (H2i), a startup incubator based in the Temerty Faculty of Medicine, Santerre has a front row seat to what he describes as a “paradigm shift.”</p> <p>He notes that H2i formed in 2014 with seven companies and generated $40,000 in economic value that year. Today, H2i comprises more than 130 early-stage health technology start-up companies that have generated over $45 million in economic value in the Toronto ecosystem this past year.</p> <p>Santerre adds that H2i has fostered several startups working in diabetes and related areas. Examples include: Nutarniq, which, in partnership with Inuit communities, is running clinical trials on a unique formulation of Omega-3 oils from seals that could alleviate secondary effects of neuropathic events associated with diabetes; and Arterial Solutions, which is commercializing an early biomarker for early peripheral vascular disease, a primary co-morbidity associated with diabetes.</p> <p>Santerre himself is chief scientific officer of Interface Biologics and Ripple Therapeutics, both venture-backed Canadian companies. Ripple Therapeutics has developed a novel drug delivery technology that could improve the efficacy and convenience of wearable insulin patches.</p> <p>“It’s really exciting what we’re seeing,” he says. “The innovation economy in Canada is creating jobs that we had never harnessed before. That is keeping our life sciences-trained experts here in Canada and is in fact attracting senior management talent to the Toronto area and drawing companies from across Canada, the U.S. and Europe to work with our homegrown companies.”</p> <p>Santerre says the impact of the insulin discovery, 100 years after the original investments, continues to be felt at Թϱ through the Connaught Awards drawn from the Connaught Fund, which was established when Թϱ sold the lab that produced insulin and other vaccines and antitoxins.</p> <p>“I know that for a fact because I was a Connaught Award recipient back in 1994, and that small investment went on to produce some 70 patents, five faculty spin-offs and the creation of the Health Innovation Hub, which is spurring a lot more health start-up activity,” he says.</p> <p>Santerre says that research, entrepreneurship and funding support from sources like the Connaught Fund as well as the recent <a href="/news/university-toronto-receives-single-largest-gift-canadian-history-james-and-louise-temerty">historic donation to the Temerty Faculty of Medicine</a> are coalescing perfectly to position Թϱ and Canada for continued leadership in diabetes research and innovation.</p> <p>“That’s the future,” he says. “We have plans afoot to scale what we’ve learned from the insulin discovery, the Connaught Labs and the impact that those revenues have had on the research and innovation machine here at Թϱ – not only for diabetes but many other diseases as well.</p> <p>“I think Canada is a sleeping giant that has awoken.”</p> <p><br> &nbsp;</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Wed, 04 Nov 2020 17:05:12 +0000 rahul.kalvapalle 166203 at