Jessamine Luck / en Clinical trial delivers chemotherapy to pediatric brain tumours using MRI-guided focused ultrasound /news/clinical-trial-delivers-chemotherapy-pediatric-brain-tumours-using-mri-guided-focused <span class="field field--name-title field--type-string field--label-hidden">Clinical trial delivers chemotherapy to pediatric brain tumours using MRI-guided focused ultrasound</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/fus_1172_20221028_-crop.jpg?h=afdc3185&amp;itok=ZthQ37_M 370w, /sites/default/files/styles/news_banner_740/public/fus_1172_20221028_-crop.jpg?h=afdc3185&amp;itok=CJZ5PR_u 740w, /sites/default/files/styles/news_banner_1110/public/fus_1172_20221028_-crop.jpg?h=afdc3185&amp;itok=jvXmc_cC 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/fus_1172_20221028_-crop.jpg?h=afdc3185&amp;itok=ZthQ37_M" alt="&quot;&quot;"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>Christopher.Sorensen</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2023-01-23T14:42:20-05:00" title="Monday, January 23, 2023 - 14:42" class="datetime">Mon, 01/23/2023 - 14:42</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item">A brain scan shows an MRI-guided focused ultrasound opening the blood-brain barrier for delivery of chemotherapy to a common brain tumour in children (photo courtesy of Sunnybrook)</div> </div> <div class="field field--name-field-author-reporters field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/authors-reporters/jennifer-palisoc" hreflang="en">Jennifer Palisoc</a></div> <div class="field__item"><a href="/taxonomy/term/6887" hreflang="en">Jessamine Luck</a></div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/breaking-research" hreflang="en">Breaking Research</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/sunnybrook-health-sciences" hreflang="en">Sunnybrook Health Sciences</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/hospital-sick-children" hreflang="en">Hospital for Sick Children</a></div> <div class="field__item"><a href="/news/tags/research-innovation" hreflang="en">Research &amp; Innovation</a></div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>A team of Toronto researchers and physicians are the first in the world to use MRI-guided focused ultrasound to open the blood-brain barrier and deliver chemotherapy to treat Diffuse Intrinsic Pontine Glioma (DIPG), an aggressive and terminal pediatric brain tumour.</p> <p>The first pediatric patient recently successfully underwent the procedure as part of a safety and feasibility clinical trial in children with this tumour.</p> <p>A challenge for treatment of DIPG is the blood-brain barrier, a protective network of cells, which can prevent therapeutics from reaching areas in the brain. In this <a href="http://sunnybrook.ca/content/?page=dipg-faq">Phase 1&nbsp;clinical trial</a>, low-intensity focused ultrasound technology is used to temporarily open the blood-brain barrier with the power of soundwaves, allowing drug treatment to cross and treat the brain tumour.</p> <p>“DIPG is a devastating pediatric brain tumour which is inoperable due to its location in the brainstem,” says&nbsp;<strong>Nir Lipsman</strong>, a neurosurgeon&nbsp;and director of&nbsp;the Harquail Centre for Neuromodulation at&nbsp;Sunnybrook Health Sciences Centre who is a co-principal investigator of the study. “Focused ultrasound is an innovative and non-invasive approach to more effectively delivering chemotherapy directly to the tumour. Our hope is that this continued research will bring us closer to enhancing treatments to help change the course of the disease.”</p> <p>Lipsman is also an associate professor of&nbsp;surgery&nbsp;at the University of Toronto’s Temerty Faculty of Medicine.</p> <p><img alt src="/sites/default/files/fus_1797_20221028_.jpg" style="width: 750px; height: 500px;"></p> <p><em>The goal of the clinical trial is to safely and temporarily open the blood-brain barrier, a layer of cells, to deliver chemotherapy to the tumour with MRI-guided focused ultrasound (photo courtesy of Sunnybrook Health Sciences Centre)</em></p> <p>“Current treatment for DIPG is limited to radiation, which can slow progression of the tumour for a period of time, but does not have longer-term effects,” says&nbsp;<strong>James Rutka</strong>, study co-principal investigator and director&nbsp;of the&nbsp;Arthur and Sonia Labatt Brain Tumour Research Centre at&nbsp;The Hospital for Sick Chlidren (SickKids).</p> <p>“Focused ultrasound technology is a promising drug-delivery strategy that is helping us penetrate the blood-brain barrier in a novel way,” adds Rutka, who is also a professor of surgery at Temerty Medicine. “Conducting this trial will help us build new and innovative treatment pathways for children with DIPG.”</p> <p>DIPG tumours are the most common form of brain tumour in children under the age of 15 and make up nearly 10 to 15 per cent of all childhood brain tumours. It affects the region of the brainstem known as the pons, which regulates the body’s involuntary activities such as breathing, heart rate and important functions such as swallowing. DIPG is considered a terminal cancer.</p> <p>Clinical and research teams from Sunnybrook and SickKids are collaborating on the clinical trial, which investigates the safety and feasibility of breaching the blood-brain barrier using MRI-guided focused ultrasound in combination with the delivery of chemotherapy in pediatric patients with DIPG.</p> <p><img alt src="/sites/default/files/fus_1415_20221028_.jpg" style="width: 750px; height: 507px;"></p> <p><em>Nir Lipsman, left, and James Rutka, right (photo courtesy of Sunnybrook)</em></p> <p>The study includes 10 patients between five and 18 years old who have been diagnosed with DIPG. Study participants receive general anesthesia ahead of focused ultrasound treatment at Sunnybrook, which will involve three cycles of chemotherapy about four to six weeks apart. A specialized helmet is used to deliver ultrasound energy to brain targets without requiring scalpels or incisions. SickKids physicians and nurses will assist with the treatment procedure at Sunnybrook, and the children will receive post-operative care at SickKids.</p> <p>Low-intensity ultrasound interacts with microscopic bubbles that vibrate causing a temporary opening in the blood-brain barrier, enabling therapies to pass and reach a targeted area. The blood brain barrier closes within hours of the procedure.</p> <p>In 2015, Sunnybrook researchers <a href="https://sunnybrook.ca/media/item.asp?i=1351">were the&nbsp;first in the world&nbsp;to investigate low-intensity focused ultrasound in the opening of the blood-brain barrier</a> and delivery of chemotherapy in adult brain cancer, and recently demonstrated in a&nbsp;trial that chemotherapy can be delivered across the blood brain barrier in brain metastases.</p> <p><img alt src="/sites/default/files/fus_0835_20221028_.jpg" style="width: 750px; height: 500px;"></p> <p><em>A team of researchers from Sunnybrook and SickKids monitor progress during treatment (photo courtesy of Sunnybrook)</em></p> <p>Sunnybrook has also continued this leading-edge focused ultrasound research in other debilitating brain disease, including&nbsp;Parkinson’s disease, Alzheimer’s disease, Amyotrophic Lateral Sclerosis, major depression&nbsp;and other disorders.</p> <p>This study was funded and supported by the Harquail family through the Harquail Centre for Neuromodulation; the Focused Ultrasound Foundation;&nbsp;and INSIGHTEC&nbsp;as well as by its lead donor at SickKids;&nbsp;Jordana’s Rainbows Foundation and the Fiorini family'&nbsp;Meagan’s Hug;&nbsp;Nelina’s Hope; and the Wiley family, who supported pre-clinical trial work.</p> <p><em>This story originally appeared at&nbsp;<a href="https://www.sickkids.ca/en/news/archive/2023/world-first-sunnybrook-sickkids-clinical-trial-chemotherapy-pediatric-brain-tumours-mri-guided-focused-ultrasound/">the&nbsp;Hospital for Sick Children</a>&nbsp;and <a href="https://sunnybrook.ca/media/item.asp?c=1&amp;i=2548&amp;f=world-first-sickkids-focused-ultrasound-cancer-pediatric">Sunnybrook Health Sciences Centre</a>.</em></p> <h3><a href="https://www.macleans.ca/society/health/qa-with-the-surgeons-who-developed-a-world-first-brain-tumour-treatment/">Read a Q&amp;A with the researchers in Maclean’s magazine</a></h3> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> Mon, 23 Jan 2023 19:42:20 +0000 Christopher.Sorensen 179198 at